Ointment for the body and face from Psoriasis (Daivobet) - 15g.

DAivobet ointment

Pharmacological properties

Calcipotriol - a synthetic analogue of the active metabolite of vitamin D. Causes inhibition of proliferation of keratinocytes and accelerates their morphological differentiation. Betamethasone - glucocorticosteroid (GCS) for external use. It has a local anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive action, but the exact mechanisms of anti-inflammatory action of topical corticosteroids is not completely clear. The use of occlusive dressings increases the effect of topical corticosteroids, because this increases their penetration into the skin.

Absorption and distribution

When applying Daivobet suction calcipotriol and betamethasone through the intact skin is less than 1%. When the drug causing psoriatic plaques and under occlusive dressings increases the absorption of topical corticosteroids. Since the skin creates a depot of the drug, its elimination from the skin occurs within a few days. Metabolism and excretion of Betamethasone is metabolized in the liver and kidneys with the formation of glucuronides and sulphation, excreted through the bowels and kidneys.  

Special instructions:

• do Not apply ointment to mucous membranes and the scalp. After the drug should wash your hands. The risk of developing hypercalcemia while adhering to the recommended dosing regimen is minimal. However, when applying Daivobet in doses exceeding the recommended maximum weekly dose (100 g), may develop hypercalcemia, quickly passing at lower doses or drug discontinuation. Daivobet contain potent corticosteroids is not recommended in the period of its use to carry out concomitant treatment with other corticosteroids. Avoid the use of the drug in extensive areas of the skin, constituting more than 30% of the body surface, and under an occlusive dressing, applied in skin folds, since it increases the likelihood of systemic absorption of corticosteroids and osteonecrosis of the jaw. When complications of psoriasis secondary infection should be antibiotic therapy, with worsening of the infection stop the drug. During treatment with Daivobet should limit or avoid excessive exposure to natural or artificial sunlight. The use of Daivobet together with UV radiation only if the potential benefit outweighs the potential risk. Use in Pediatrics Clinical experience in the application of Daivobet in children and adolescents under 18 years of absence. Effects on ability to drive vehicles and other mechanisms that require high concentration Daivobet does not affect the ability to drive vehicles and management mechanisms..

Indications:

• vulgar Chronic plaque Psoriasis.

product Form:

• Ointment for external application.

composition: 

1 g ointment for external use contains: Active substances: betamethasone dipropionate 643 micrograms, equivalent to 500 micrograms betamethasone; calcipotriol monohydrate 52 µg, equivalent calcipotriol 50 mcg. Excipients: liquid paraffin, polyoxypropylene-15-stearyl ether, α-tocopherol white soft paraffin.

Net and packing: 

-  15  g. Aluminum tube white color with twist-off lid.

English name: 

- Daivobet ointment. 15g.
 

application: 

- Adults: topical ointment applied in a thin layer to affected skin 1 time/day. Maximum daily dose is not more than 15 g, the maximum weekly dose should not exceed 100 g. the recommended duration of treatment - 4 weeks. It is possible to conduct repeated courses of treatment under medical supervision. The area of application of the drug should not exceed 30% of the body surface.

Note:

• Store in a cool dry place away from direct sunlight, out of reach of children.
• Contraindications:
Diseases associated with impaired metabolism of calcium; renal and liver failure; virus (including herpes or chickenpox ) infection; fungal skin infection; bacterial skin infection; parasitic infection of the skin; rosacea; acne rosacea; acne vulgaris; perioral dermatitis; cutaneous manifestations of tuberculosis and syphilis; skin atrophy; skin ulceration; increased fragility of blood vessels of the skin; ichthyosis; perianal and genital itching; psoriatic erythroderma; guttate, exfoliative, pustular psoriasis; hypersensitivity to the drug..

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